ARPAH Rare Disease Diagnostics

The Department of Health and Human Services, National Institutes of Health, Advanced Research Project Agency for Health has a requirement for ARPA-H PROactive Solutions for Prolonging Resilience.

Solicitation Summary

The Department of Health and Human Services, National Institutes of Health, Advanced Research Project Agency for Health has a requirement for ARPA-H PROactive Solutions for Prolonging Resilience.

Solicitation in a Nutshell

Item

Details

Agency Department of Health and Human Services, National Institutes of Health, Advanced Research Project Agency for Health
Solicitation Number ARPAHSN25127
Status Post-RFP
Solicitation Date 01/18/2025
Award Date 08/2025 (Estimate)
Contract Ceiling Value  To Be Determined
Competition Type  Full and Open / Unrestricted
Type of Award  Other Transaction Agreement
Primary Requirement  Research & Development
Duration  54 month(s) base
Contract Type  Other Transaction Agreement
No. of Expected Awards  Multiple – Number Unknown
NAICS Code(s):
541715

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
Size Standard: 1000 Employees except 1500 Employees for Aircraft, Aircraft Engine and Engine Parts, 1250 Employees for Other Aircraft Parts and Auxiliary Equipment and 1300 Employees for Guided Missiles and Space Vehicles, Their Propulsion Units and Propulsion Parts

Place of Performance:
  • United States
Opportunity Website: https://sam.gov/opp/74313f88a78741f39d2fe33e451e1075/view

Background

Collectively, rare diseases are far from rare — more than 10,000 unique conditions affect over 350 million people worldwide, including one in ten Americans. The lengthy diagnostic “odyssey” endured by patients with a rare disease lasts six years on average but can extend for decades. Diagnostic delays stem from multiple factors, including overlapping symptoms, low disease incidence, and limited specialist expertise. It’s estimated that half of all individuals with a rare disease remain undiagnosed or misdiagnosed, leading to inappropriate care, irreversible disease progression, and rising medical costs

Requirements

  • The Rare Disease AI/ML for Precision Integrated Diagnostics (RAPID) program aims to transform the diagnosis of rare and ultra-rare diseases by developing highly accurate AI-based detection models. RAPID seeks to develop provider-facing tools that prioritize data interoperability and integration into existing clinical workflows, ensuring scalability across health care organizations. RAPID will also design cost effective, direct-to-patient systems that can be remotely deployed to help individuals and their families detect rare diseases at home or in non-clinical settings and route them toward appropriate medical support. To catalyze model development, RAPID aims to integrate data from a fragmented landscape, building the largest curated dataset of longitudinal rare disease patient data that is optimized for training and benchmarking advanced diagnostic algorithms. If successful, RAPID will expand access to rare disease expertise and help patients and health care providers reach an accurate diagnosis in a fraction of the time it takes today.

How can GDIC Help?

As a consulting firm that specializes in helping companies prepare winning proposals for government contracts, GDIC can provide a wide range of services to help offerors prepare their C2E proposal, including capture management, proposal writing, proposal management, and proposal review. GDIC can also provide training and support to help offerors understand the technical and administrative requirements outlined in the solicitation, and can provide guidance on how to structure the proposal to maximize its chances of success.

Our business development and proposal professionals have several decades of experience and expertise in construction proposals and contracts for government. By working with GDIC, offerors can increase their chances of winning the C2E contract and can position themselves for long-term success in the federal marketplace.